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The combination of the know-how of Apha Biomat and Meccellis Biotech:
Innovative and bringing hope
to patients around the world : XENOPHA

The P4HB is produced by natural fermentation

The P4HB is a PHA (polyhydroalkanoate) biopolymer. It is recognized for its biocompatible properties. It is made up of monomers naturally present in the human body. Once implanted, P4HB is degraded by hydrolysis.

Reduce our impact on the environment

The use of biopolymers in the medical field is one of the solutions to meet the environmental and health challenges we face. By using biodegradable and non-toxic materials, we can reduce our impact on the environment while improving the health and well-being of patients and we are proud to contribute to this. We are convinced that biopolymers have a crucial role to play in the future of medicine and we are delighted to be part of this sustainable medical revolution.

Xenopha

Xenopha

These products are not yet approved for market release and, consequently, are not yet available for sale.

Xenopha AWR mesh

Despite advances in techniques and available materials, parietal reconstructive surgery continues to face significant clinical challenges. Postoperative complications  such as hernia recurrence, infections, or chronic pain  remain major limitations to the effectiveness of current solutions. This reality underscores the need for a novel medical device specifically designed to optimize tissue integration, reduce complication rates, and enhance the durability of outcomes. The development of such an innovation would be a pivotal lever for strengthening the quality of surgical care and meeting increasingly stringent public health standards.

illustration of the biological matrix xenopha for abdominal wall repair
Illustration de la prothèse mammaire Xenopha 3D Breast
Xenopha 3D Breast matrix

In breast reconstruction, the use of silicone has long been considered the benchmark solution, but its clinical and biological limitations are now well established. The complications associated with it highlight the need to explore new avenues. Research in biomaterials opens up promising prospects, with the development of more biocompatible solutions that better integrate with tissues and offer superior durability. Within this dynamic, our innovative device represents a concrete response to current limitations: it aims to significantly enhance both patient safety and comfort, while setting new standards of quality and effectiveness in breast reconstruction.

These innovations have been developed in partnership with Meccellis Biotech, a French company specializing in tissue engineering.

In my practice of post-mastectomy breast reconstructive surgery, I have observed the growing importance of, in the future, having so-called ‘colonizable’ breast implants—designed to allow the gradual integration of the patient’s own biological tissues.


These next‑generation implants would represent a significant advance in breast reconstruction. They could offer major surgical and functional benefits:

  • Enhanced tissue integration: colonization by surrounding tissues would promote natural stabilization of the prosthesis, thereby reducing the risks of displacement or rotation.

  • Reduction of capsular fibrosis: thanks to improved biological tolerance, these implants would reduce the chronic inflammatory reactions responsible for capsule formation.

  • More durable and natural outcome, featuring a supple feel and physiological response to body movement.

  • Improved safety, particularly in immediate reconstructions or post-radiotherapy settings, where tissues are often compromised.


Beyond their surgical value, these devices would profoundly impact patients’ care journeys. Often, they would reduce the number of secondary interventions and help restore a stable and satisfying body image, with tangible psychological benefits.


Pr Laurent LANTIERI
Chef de service • HEGP Paris
Photo du professeur Laurent Lantieri

P4HB Biopure

Discover BioPure, our medical‑grade purified P4HB, available in two formats to meet your needs:

 

• Powder, ideal for formulation and material development

• Filament for 3D printing, for advanced prototyping and manufacturing applications.


For any inquiries or technical information, please contact us directly. We would be delighted to support you in your projects.


These products are not implantable and are intended for companies only, for their development purposes.

French manufacturer of medical grade biopolymer (P4HB)

Team

Team
  • Fabien Dolbeau

    COO

  • Anthony PéRèS

    CTO

  • Guillaume HOFMANSKI

    Director of clinical relations

  • Emilie ALAZARD PéRèS

    Industrial manager

  • Claire CISTERNI

    Clinical affairs manager

  • Sophie RENÉ

    Quality and Regulatory Affairs Manager

  • Morgane COUSSINE

    Production operator

  • Cassandra POUVREAU

    Production operator

  • Béatrice KONIECZNY

    Accountant secretary

Sponsors

News

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  • associés meccellis biotech

    At Chef de Baie (France), a company has been working for twelve years to revolutionise parietal surgery, (…)

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  • La Rochelle : an SME that invents the future of implants for breast surgery

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  • Emergence 2023 : Apha Biomat receives the collaborative innovation award

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  • La Rochelle : PH Tech start-up raises 5 million euros to develop

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75 rue de Québec 17000 La Rochelle - France

+33 (0) 5 17 81 07 63

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